Original Zeus Player Edition football shirt AS Varese 2014/15

In 1914 the club played in a league for the first time, a year later football in most parts of Europe was shut down by the First World War, after the war football was resumed. In 1926, the club colors of red and white were adopted in accordance with Varese's colours. In the Masnago district, the stadium became Stadio del Littorio. In 1950 the name of the stadium was changed to Stadio Franco Ossola, in tribute to Franco Ossola who had transferred from Varese to AC Torino and died in the Superga plane crash in 1949.

In 1964, the club was promoted to Serie A after two successive promotions. In the first season, the club finished eleventh and then relegated. In Serie B, Varese became vice champion behind Sampdoria Genoa and was promoted back. On their return, the club tied for seventh with Torino. Also this time, the club relegated in the second season. In Serie B, Varese became champions by one point over US Foggia and Catania. The third stay in Serie A was no different from the two previous ones, after a ninth place in 1971 the club became last in 1972. Now it took two seasons before Varese returned to Serie A. This time it was the last appearance of the club in the highest division.

After relegation from Serie B in 1985, the club could not return. The following years were spent in the Serie C1 and Serie C2. Due to mismanagement, the club ran into financial difficulties and went bankrupt in July 2004. The new club AS Varese 1910 started in the Eccellenza (sixth division) and then promoted up four divisions and played in the second division from 2010/11 until they closed in 2015. relegated to Serie C1. However, they could not pay the registration fee, so they were declared bankrupt. Under the new name of Varese Calcio SSD, they started again in the Eccellenza, where they promoted to Serie D (4th level in Italy) after a season. After the 2018/19 season, things went wrong again at the club and on August 12, 2019 it was declared bankrupt. The club decided not to make a new start and no longer registered for the 2019/20 competition meer