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The Michigan State Spartans football program represents Michigan State University (MSU) in college football at the NCAA Division I Football Bowl Subdivision (FBS) level. The Spartans are members of the Big Ten Conference. Michigan State claims a total of six national championships, including two (1952, 1965) from the major wire-service: AP Poll and/or Coaches' Poll. The Spartans have also won eleven conference championships, with two in the Michigan Intercollegiate Athletic Association and nine in the Big Ten.

Home games of the Spartans are played at Spartan Stadium, which is located on the main university campus. Spartan Stadium is consistently ranked among the NCAA's top 25 in attendance. The Spartans are led by head coach Jonathan Smith.