On 23 May 2016, Pellè was included in the pre-selection for the 2016 European Football Championship in France. Pellè survived the selection and became the Italian number 9 for the European Championship. He accounted for the second goal in the first group game against Belgium (2–0 win), which was played on Monday June 13, 2016 in Lyon. The selection previously called by pessimists The worst Italy of all time was already after two duels already in the eighth final, in which the national coach Pellè proved the missing link for success. In the eighth final, Spain was beaten 2-0 thanks in part to a goal by Pellè, who was elected man of the match. Italy was eliminated by Germany in the quarterfinals after penalties. On Friday, October 7, 2016, the day after the World Cup qualifier against Spain (1-1), Pellè was removed from the Italian selection for the next World Cup qualifying match against Macedonia due to misconduct. National coach Giampiero Ventura made that decision in response to the attacker's behavior after his substitution in the game against Spain. Pellè was visibly angry when he had to clear the field shortly after the break in favor of Ciro Immobile and refused to shake the coach. "When wearing the national shirt, there are certain values, such as showing respect to the staff, teammates and fans. This behavior does not fit with that," said a statement Pellè offered to his teammates and his Instagram account afterwards. apologies. "Sure enough, unfortunately I made a mistake again. As with any misstep, you have to accept the consequences. I take full responsibility and apologize."